CAS No. 75-05-8
Catalog No. 655668
Acetonitrile Solution Synonyms:
Acetonitril;acetonitril(german,dutch) ;CH3CN;Cyanomethan;Acetonitrilo;CH3CN;cianometano;cianuro di metile;cyanomethane;Cyanure de methyl;etanonitrile;Ethane nitrile;Ethanenitrile;Ethyl nitrile;MeCN;Methane, cyano-;methyl cyanide;Methylidyne, cyano-
0.982 g/mL at 20 °C
1.41 (vs air)
72.8 mm Hg ( 20 °C)
organic solvents: soluble(lit.)
Stability Unstable. Incompatible with alkali metals, acids, bases, reducing agents and oxidizing agents. Highly flammable
It may be used as a solvent to prepare:
• 1,2-Azidoalcohols and 1,2-azidoamines via cerium(III) chloride assisted ring opening of epoxides and aziridines by sodium azide.
• Cyano-bearing indolinones by oxidative arylalkylation of olefins in the presence of palladium catalyst.
It may also be used as a reactant to synthesize:
• Bis (diphenylphosphino) by reacting with n-butyllithium and then with chlorodiphenylphosphine.
• β-Acetamido ketones via coupling reaction with ketones or ketoesters and aldehydes in the presence of cobalt(II) chloride.
The product contains 0.1%v/v trifluoroacetic acid. This pre-blended mobile phase solvent is of high purity that reduces time-consuming preparation and prevents instrument downtime because of impure mobile phases. Trifluoroacetic acid mobile phase system is generally employed for peptide separation. (MeCN), an organic solvent has low viscosity, high elution strength and is UV transparent at low wavelength. Trifluoroacetic acid (TFA) is commonly used as a mobile phase additive. It is a volatile acid that forms hydrophobic negatively charged trifluoroacetate ion.