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diethyl cyanomethylphosphonate

CAS No. 2537-48-6 | Catalog No. 655307


Synonyms
LABOTEST-BB LT00233137;DEPAN;CYANOMETHANEPHOSPHONIC ACID DIETHYL ESTER;CYANOMETHYLPHOSPHONIC ACID DIETHYL ESTER;DIETHYL CYANOMETHYLPHOSPHONATE;(DIETHYLPHOSPHONO)ACETONITRILE;(Cyanomethyl)diethoxyphosphine oxide;2-(Diethylphosphonyl)acetonitrile


Properties

Boiling Point 101-102 °C0.4 mm Hg(lit.)
Form Liquid

Application
It is used as an intermediate in Horner-Emmons reaction for the synthesis of substituted nitriles and their amide and heterocyclic derivatives. It is known as a modified Wittig reagent used in the preparation of alpha; beta-unsaturated nitriles from ketones or aldehydes like 3-hydroxy-3-methylbutanal. It reacts with epoxides and nitrones to prepare cyano-substituted cyclopropanes and aziridines respectively. It is actively involved in the synthesis of alpha-arylated alkanenitriles via reaction with aryl iodides in presence of CuI.

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