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4′-(methylthio)acetophenone

CAS No. 1778-09-02 | Catalog No. 655356


Synonyms
Ethanone; 1-[4-(methylthio)phenyl]-;4-(Methyl thio);Ethanone;1-[4-(methylthio);4-THIOMETHYLACETOPHENONE;Dodecane-1-sulfonyl chloride;1-Acetyl-4-(methylthio)benzene;Methyl 4-acetylphenyl sulfide


Properties

Boiling Point 135 °C
Melting Point 80-82 °C(lit.)

Application
It may be used for the synthesis of Vioxx (Rofecoxib); an non-steroidal anti-inflammatory drug (NSAID). It may be used in the synthesis of (E)-1-[4-(methylsulfanyl)phenyl]-3-phenylprop-2-en-1-one.


General Description
It is a sulphur containing organic building block. It is a key intermediate in drug synthesis. Its industrial preparation; via Friedel-Crafts acylation reaction in the presence of aluminium chloride as catalyst and acetyl chloride as acylating agent has been reported. It has been prepared by the acetylation reaction of thioanisole with acetic anhydride in the presence of solid acid catalyst.

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