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N,O-bis(trimethylsilyl)acetamide

CAS No. 10416-59-8 | Catalog No. 655261


Synonyms
dynasylan bsa;BIS(TRIMETHYLSILYL)ACETAMIDE;Acetimidic acid; N-(trimethylsilyl)-; trimethylsilyl ester;CB2500;Ethanimidicacid;N-(trimethylsilyl)-;trimethylsilylester ;N-(Trimethylsilyl)acetimidic acid; trimethylsilyl ester


Properties

Boiling Point 71-73 °C35 mm Hg(lit.)
Form Crystalline Powder, Crystals and/or Chunks
Melting Point 24 °C
Solubility Miscible with many nonpolar and polar aprotic solvents.

Application
It is used as a regioselective desulfation reagent as well as a preparatory agent for carbohydrate and alcohol trimethylsilyl ethers. It is also used for the derivatization of polar functional groups such as carboxylic acids; phenols; steroids; amines; alcohols; alkaloids and amides. It is employed in the formation of stable trimethylsilyl derivatives. Further; it is used in analytical chemistry for the derivatization of compounds in analysis to increase their volatility and to introduce the trimethylsilyl protecting group in organic synthesis. In addition to this; it is used in the protection of hydroxyl groups in natural products; functional groups in organic intermediates and derivatization reagent for gas chromatography-Mass spectral analysis of phenolic acids in fruits.

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