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p-tolyl isothiocyanate

CAS No. 622-59-3 | Catalog No. 655688


Synonyms
TIMTEC-BB SBB008290;isothiocyanicacid;4-tolylester ;p-Tolylisothiocyanate;97%;4-METHYLPHENYL ISOTHIOCYANATE 99+%;Isothiocyanic Acid p-Tolyl Ester 4-Methylphenyl Isothiocyanate


Properties

Boiling Point 237 °C(lit.)
Melting Point 25-26 °C(lit.)

Application
It has been used in the preparation of 6-[1-amino-3-(p-tolyl)-thiourea]-2-ethylbenzo[de]isoquinoline-1;3-dione. It is used as capping agent to cap the N-terminal ends of polypeptide. It is also used as pharmaceutical intermediate. Ithas been used: • in the preparation of 6-[1-amino-3-(p-tolyl)-thiourea]-2-ethylbenzo[de]isoquinoline-1;3-dione • as capping agent to cap the N-terminal ends of polypeptides


General Description
It reacts with 6-hydroxy-2;4;5-triaminopyrimidine or with 4;5;6-triaminopyrimidine in DMF and triethylamine to yield 2;4-diamino-5-(p-tolylthioureido)aminopyrimidin-6-one and 4;6-diamino-5-(tolylthioureido)aminopyrimidine; respectively.

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